The QE Placebo

I invented the Placebo Camera.

So firstly, trials against placebo everybody thinks they know that a trial should be a comparison of your new drug against placebo.

And of course, also there's the placebo effect.

But, actually, the point of placebo education is interesting.

And yet, repeatedly, you consistently see people doing trials still against placebo.

So we do random assignment, placebo controlled, long term studies of different interventions.

The placebo effect is one of the most fascinating things in the whole of medicine.

So we know that our beliefs and expectations can be manipulated, which is why we do trials where we control against a placebo where one half of the people get the real treatment and the other half get placebo.

By limiting the study population to children in the other two groups, for whom exogenous growth hormone stimulates normal growth, researchers achieved a 100 relative treatment difference. In other words, every subject who received the active drug responded, and none of those who received the placebo did.

Someone was actually suggesting that you can take this concept further, and actually produce placebo education.

And this has been demonstrated in a whole raft of fascinating studies comparing one kind of placebo against another.

The amazing thing is another company did the right scientific trial, where they gave half placebo and half the drug.

I mean, look, it doesn't take a double blind, placebo controlled study to figure out what makes a marriage not work.

Would you want your mother, your brother, your sister to get a placebo if they had advanced lung cancer and had weeks to live?

Convincing studies of drugs and surgical procedures usually come only from randomized trials, in which patients receive treatment or don t according to a process analogous to a coin flip. Well conducted randomized trials incorporate additional safeguards against bias, including use of placebo medication that allows investigators to blind patients and caregivers to whether patients are, or are not, receiving active treatment.

They had gotten their chemotherapy, and then they randomized them, where half got placebo, and half got a drug called Zoledronic acid that builds bone.

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But they did that, and what they found is that 70 percent of the non responders lived much longer and did better than people who got placebo.

And he had a big jar full of placebo pills that he would give them, and he'd say, Come back in a week, if you still feel lousy.

And then we were able to test them rigorously, in random assignment, placebo controlled designs, throw out the things that didn't work, keep the things that actively did.

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Chintu C., Bhat GJ, Walker AS, et. al., Co trimoxazole as prophylaxis against opportunistic infections in HIV infected Zambian children (CHAP) a double blind randomised placebo controlled trial , Lancet 2004 365 1865 71.

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