And the other really interesting thing is that when skeletal muscle there's been several reports that when skeletal muscle is injured, that's what correlates with metastases going to skeletal muscle.

Some of my hypotheses are that when you first think about skeletal muscle, there's a lot of blood vessels going to skeletal muscle.

So, is it possible that the tumor cells are going to the skeletal muscle tissue, but once in contact inside the skeletal muscle tissue, MyoD acts upon these tumor cells and causes them to become skeletal muscle cells?

So these articles were saying, you know, Skeletal metastasis to skeletal muscle is very rare.

Some articles even went as far as to say that skeletal muscle tissue is resistant to cancer, and furthermore, not only to cancer, but of metastases going to skeletal muscle.

Is it possible that skeletal muscle doesn't express this type of molecules?

I mean, there are so many possibilities for why tumors don't go to skeletal muscle.

So I decided to ask why. At first the first thing I did was I emailed some professors who specialized in skeletal muscle physiology, and pretty much said, Hey, it seems like cancer doesn't really go to skeletal muscle.

Now, one thing that kind of ties the resistance of skeletal muscle to cancer to the cancer as a repair response gone out of control in the body is that skeletal muscle has a factor in it called MyoD.

16 percent! Meaning that there were these pinpoint tumors in skeletal muscle, but only .16 percent of actual metastases suggesting that maybe skeletal muscle is able to control the angiogenesis, is able to control the tumors recruiting these blood vessels.

But then again, this fact that the metastases didn't go to skeletal muscle made that seem unlikely.

And skeletal muscle constitutes 50 percent of our body, or over 50 percent of our body. And so at first I kind of thought, Well, maybe there's some obvious explanation why skeletal muscle doesn't get cancer at least not that I know of.

And one article that really stood out to me when I was just reading about this, trying to figure out why cancer doesn't go to skeletal muscle, was that it had reported 16 percent of micro metastases to skeletal muscle upon autopsy.

Therefore, when a tumor comes into skeletal muscle tissue, it can't get a blood supply, and can't grow.

So the fact that not only did cancer not seem to originate in skeletal muscles, but cancer didn't seem to go to skeletal muscle there seemed to be something here.

But it struck me that I'd never heard of cancer of the heart, or cancer of any skeletal muscle for that matter.

Maybe tumor cells are being disguised as skeletal muscle cells, and this is why it seems as if it is so rare.

And what MyoD essentially does is, it causes cells to differentiate into muscle cells. So this compound, MyoD, has been tested on a lot of different cell types and been shown to actually convert this variety of cell types into skeletal muscle cells.

Another important sector of activity exploits viral vectors based on the adeno associated virus to deliver to the heart and the skeletal muscle different genes that induce therapeutic angiogenesis and tissue regeneration.

At a BMI above 30, these subjects are deemed metabolically healthy obese. Like obese patients suffering from cardio metabolic risks (the metabolically abnormal obese ), they have high visceral and subcutaneous fat mass, though metabolically healthy obese patients sometimes have excessive body fat but lower fat infiltration in the liver and in skeletal muscle.

And, furthermore, when skeletal muscle is injured, that's what causes chemokines these signals saying, Cancer, you can come to me, the go signs for the tumors it causes them to highly express these chemokines.

The skeletal structure's completely normal.

You see the skeletal structure of it.

So this suggests that maybe if there is an anti angiogenic factor in skeletal muscle or perhaps even more, an angiogenic routing factor, so it can actually direct where the blood vessels grow this could be a potential future therapy for cancer.

Only a skeletal staff is present inside the country.

Don't move a muscle.

Okay. What's the muscle for?

That's what you're seeing here. You're seeing this muscle bio reactor actually exercising the muscle back and forth.

So first of all I thought, you know, Wouldn't it be favorable to cancer getting to skeletal muscle? And as well, cancer tumors require a process called angiogenesis, which is really, the tumor recruits the blood vessels to itself to supply itself with nutrients so it can grow.

Charles Limb Building the musical muscle

And I'm peeling that muscle away.

The cat didn't move a muscle.

Drawn to his muscle and brawn

Right, now, don't move a muscle.

This is actually showing a piece of muscle and how we go through the structures to actually engineer the muscle.

Turns out, Tony's got the philosophy muscle.

So the muscle contracts, and nothing happens.

Turns out, Tony's got the philosophy muscle.

Muscle is constantly being used constantly being damaged.

You place the muscle cells on the outside.

We coat the outside with these muscle cells.

We then start adding the muscle on top.

And don't let anybody try to muscle in.

We got the best muscle on the waterfront.

We take muscle cells, we paste, or coat the outside with these muscle cells, very much like baking a layer cake, if you will.