Over time, if uncorrected, major depression can cause such conditions as progressive mineral loss from bones, accumulation of abdominal fat, increased blood platelet reactivity, and increased risk of cardiovascular disease. Moreover, certain types of antidepressants may contribute to some of these conditions.

This variation of the genome is exceptionally common, present in 30 of individuals of European ancestry and more than 50 of those of Asian ancestry. In many such patients, doubling the dose of Plavix, and checking the platelet function with a point of care test to assure suppression, can override the lack of response.