Do Antioxidant Supplements Work?

Some clinical trials were terminated prematurely because harmful effects of antioxidant supplements were observed. Indeed, the overwhelming evidence currently calls into question the preventive effect of antioxidant pills.

Indeed, consumption of antioxidant supplements in developed countries has become widespread. More than one third of adults in developed countries now ingest antioxidant pills, which is much easier than eating fruits and vegetables.

There are still many gaps in our knowledge of the mechanisms of action of antioxidant supplements. Basic issues concerning the efficacy and safety of consuming relatively high doses of antioxidant supplements need to be resolved.

By eliminating free radicals from our body, we interfere with important defensive mechanisms for eliminating damaged cells, including cancerous cells. So antioxidant substances can also harm people.

In fact, the amounts of antioxidants that lend protection are not known and probably differ among individuals. People exposed to increased oxidative stress may have elevated antioxidant requirements.

And the genes it turns on includes antioxidant genes, genes I call carrot giver genes, whose protein products actually help other proteins to function well to fold correctly and function correctly.

So far, many studies have been conducted to verify the supposed beneficial effects of antioxidant supplements. But, while the results of epidemiological studies have been almost uniformly positive, the results of clinical trials have remained largely inconclusive.

The main role of antioxidants is to prevent oxidative damage to cellular components, so it has been proposed that dietary antioxidants decrease such damage and with it the risk of disease. This has stimulated interest in the possible preventive potential of antioxidant supplements.

As with any therapeutic intervention, the most convincing and direct proof of the preventive efficacy of antioxidant supplements requires randomized, controlled clinical trials. Such trials eliminate the problems of participants dietary record and controls the effects of both known and unknown confounding factors.

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